TOR Complexes and the Maintenance of Cellular Homeostasis.
Identifieur interne : 000996 ( Main/Exploration ); précédent : 000995; suivant : 000997TOR Complexes and the Maintenance of Cellular Homeostasis.
Auteurs : Sandra Eltschinger [Suisse] ; Robbie Loewith [Suisse]Source :
- Trends in cell biology [ 1879-3088 ] ; 2016.
Descripteurs français
- KwdFr :
- Complexe-1 cible mécanistique de la rapamycine (MeSH), Complexe-2 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (physiologie), Homéostasie (génétique), Humains (MeSH), Levures (MeSH), Métabolisme lipidique (physiologie), Phénomènes physiologiques cellulaires (MeSH), Sérine-thréonine kinases TOR (physiologie), Taille de la cellule (MeSH).
- MESH :
English descriptors
- KwdEn :
- Cell Physiological Phenomena (MeSH), Cell Size (MeSH), Homeostasis (genetics), Humans (MeSH), Lipid Metabolism (physiology), Mechanistic Target of Rapamycin Complex 1 (MeSH), Mechanistic Target of Rapamycin Complex 2 (MeSH), Multiprotein Complexes (physiology), TOR Serine-Threonine Kinases (physiology), Yeasts (MeSH).
- MESH :
- chemical , physiology : Multiprotein Complexes, TOR Serine-Threonine Kinases.
- chemical : Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2.
- genetics : Homeostasis.
- physiology : Lipid Metabolism.
- Cell Physiological Phenomena, Cell Size, Humans, Yeasts.
Abstract
The Target of Rapamycin (TOR) is a conserved serine/threonine (ser/thr) kinase that functions in two, distinct, multiprotein complexes called TORC1 and TORC2. Each complex regulates different aspects of eukaryote growth: TORC1 regulates cell volume and/or mass by influencing protein synthesis and turnover, while TORC2, as detailed in this review, regulates cell surface area by influencing lipid production and intracellular turgor. TOR complexes function in feedback loops, implying that downstream effectors are also likely to be involved in upstream regulation. In this regard, the notion that TORCs function primarily as mediators of cellular and organismal homeostasis is fundamentally different from the current, predominate view of TOR as a direct transducer of extracellular biotic and abiotic signals.
DOI: 10.1016/j.tcb.2015.10.003
PubMed: 26546292
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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In this regard, the notion that TORCs function primarily as mediators of cellular and organismal homeostasis is fundamentally different from the current, predominate view of TOR as a direct transducer of extracellular biotic and abiotic signals. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26546292</PMID><DateCompleted><Year>2016</Year><Month>11</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-3088</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Trends in cell biology</Title><ISOAbbreviation>Trends Cell Biol</ISOAbbreviation></Journal><ArticleTitle>TOR Complexes and the Maintenance of Cellular Homeostasis.</ArticleTitle><Pagination><MedlinePgn>148-159</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0962-8924(15)00190-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.tcb.2015.10.003</ELocationID><Abstract><AbstractText>The Target of Rapamycin (TOR) is a conserved serine/threonine (ser/thr) kinase that functions in two, distinct, multiprotein complexes called TORC1 and TORC2. Each complex regulates different aspects of eukaryote growth: TORC1 regulates cell volume and/or mass by influencing protein synthesis and turnover, while TORC2, as detailed in this review, regulates cell surface area by influencing lipid production and intracellular turgor. TOR complexes function in feedback loops, implying that downstream effectors are also likely to be involved in upstream regulation. In this regard, the notion that TORCs function primarily as mediators of cellular and organismal homeostasis is fundamentally different from the current, predominate view of TOR as a direct transducer of extracellular biotic and abiotic signals. </AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Eltschinger</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology, University of Geneva, Geneva, Switzerland; iGE3 Institute of Genetics and Genomics of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loewith</LastName><ForeName>Robbie</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Molecular Biology, University of Geneva, Geneva, Switzerland; iGE3 Institute of Genetics and Genomics of Geneva, Geneva, Switzerland; National Centre for Competence in Research in Chemical Biology, Geneva, Switzerland. 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